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AMG 548

Catalog #: 3920
3 Citations Datasheet
Catalog # Availability Size / Price Qty
3920/10
AMG 548 | CAS No. 864249-60-5 | p38 Inhibitors
1 Image
Description: Potent and selective p38α inhibitor

Chemical Name: 2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone

Purity: ≥98%

Product Details
Citations (3)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis.

Technical Data

M.Wt:
461.56
Formula:
C29H27N5O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
864249-60-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. p38 MAP kinase inhibitors: many are made, but few are chosen.
    Dominguez et al.
    Curr.Opin.Drug Discov.Devel., 2005;8:421
  2. MAP kinase p38 inhibitors: clinical results and an intimate look at their interactions with p38α protein.
    Lee and Dominguez
    Curr.Med.Chem., 2005;12:2979

Product Datasheets

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Citations for AMG 548

The citations listed below are publications that use Tocris products. Selected citations for AMG 548 include:

3 Citations: Showing 1 - 3

  1. Small Molecule Arranged Thermal Proximity Coaggregation (smarTPCA)-A Novel Approach to Characterize Protein-Protein Interactions in Living Cells by Similar Isothermal Dose-Responses.
    Authors: Kai Et al.
    Int J Mol Sci  2022;23
  2. The cellular thermal shift assay for evaluating drug target interactions in cells.
    Authors: Rozbeh Et al.
    Nat Protoc  2014;9:2100-22
  3. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium.
    Authors: Eckle Et al.
    J Biol Chem  2013;11:e1001665

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