AMD 3465 hexahydrobromide
Chemical Name: N-[[4-(1,4,8,11-Tetraazacyclotetradec-1-ylmethyl)phenyl]methyl]-2-pyridinemethanamine hexahydrobromide
Purity: ≥97%
Biological Activity
AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist; exhibits 8-fold higher affinity than AMD 3100 (Cat.No. 3299). Inhibits SDF-1α-ligand binding (Ki = 41.7 nM). Potently inhibits HIV cell entry in vitro; causes leukocytosis and mobilizes haematopoietic stem cells in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
Lourenco S, Teixeira V, Kalber T, Jose R, Floto R, Janes S
J Immunol, 2015;194(7):3463-74. -
Comparison of cell-based assays for the identification and evaluation of competitive CXCR4 inhibitors
A Van Hout, T D'huys, M Oeyen, D Schols, T Van Loy
PLoS ONE, 2017;12(4):e0176057. -
Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor.
Rosenkilde et al.
J.Biol.Chem., 2007;282:27354 -
Pharmacology of AMD3465: A small molecule antagonist of the chemokine receptor CXCR4.
Bodart et al.
Biochem.Pharmacol., 2009;78:993
Product Datasheets
Citations for AMD 3465 hexahydrobromide
The citations listed below are publications that use Tocris products. Selected citations for AMD 3465 hexahydrobromide include:
3 Citations: Showing 1 - 3
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Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain.
Authors: Luo Et al.
Mol Pain 2016;12
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Identification of Therapeutic Targets of Inflammatory Monocyte Recruitment to Modulate the Allogeneic Injury to Donor Cornea.
Authors: David L Et al.
Invest Ophthalmol Vis Sci 2015;56:7250-9
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Macrophage migration inhibitory factor-CXCR4 is the dominant chemotactic axis in human mesenchymal stem cell recruitment to tumors.
Authors: Lourenco Et al.
J Immunol 2015;194:3463
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