α-Mangostin

Biological Activity

α-Mangostin is a xanthone derivative. Inhibits proliferation and induces apoptosis selectively in pancreatic CSCs and cancer cell lines. Also suppresses the invasive and metastatic ability of pancreatic CSCs by modulation of cadherin expression and suppressing the transcription factors Snail and Slug. Attenuates the expression of Nanog and pluripotency promoting transcription factors, and inhibits Nanog binding. Downregulates the PI 3-K/Akt pathway. Inhibits self-renewal of CSCs isolated from human primary tumors and KrasG12D mice. Inhibits MRSA and VRE. Antibacterial, antifungal, antimalarial, anticarcinogenic, antiatherogenic, anti-inflammatory, antioxidant and neuroprotective.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Inhibition of pancreatic cancer stem cell characteristics by a-Mangostin: Molecular mechanisms involving Sonic hedgehog and Nanog.
   Ma et al.
   J.Cell Mol.Med., 2019;23:2719
2. Pharmacology of mangostins and their derivatives: A comprehensive review.
   Wang et al.
   Chin.J.Nat.Med., 2017;15:81

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