Akti-1/2

Catalog # Availability Size / Price Qty
5773/10
5773/50
Akti-1/2 | CAS No. 612847-09-3 | Akt (Protein Kinase B) Inhibitors
1 Image
Description: Potent and selective dual Akt1 and 2 inhibitor
Alternative Names: Akt Inhibitor VIII

Chemical Name: 1,3-Dihydro-1-[1-[[4-(6-phenyl-1H-imidazo[4,5-g]quinoxalin-7-yl)phenyl]methyl]-4-piperidinyl]-2H-benzimidazol-2-one

Purity: ≥98%

Product Details
Citations (11)
Supplemental Products
Reviews

Biological Activity

Akti-1/2 is a potent and selective dual Akt1 and 2 inhibitor (IC50 values are 50 and 210 nM, respectively). Selective for Akt1 and 2 over a panel of other tyrosine and serine/threonine kinases. Sensitizes LnCaP cells to TRAIL (TNF-related apoptosis-inducing ligand) induced apoptosis. Also enhances CAR and TCR retroviral transduction of human T cells. Active in vivo.

Technical Data

M.Wt:
551.64
Formula:
C34H29N7O
Solubility:
Soluble to 20 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
612847-09-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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Citations for Akti-1/2

The citations listed below are publications that use Tocris products. Selected citations for Akti-1/2 include:

11 Citations: Showing 1 - 10

  1. TSC22D4 interacts with Akt1 to regulate glucose metabolism.
    Authors: Adriano Et al.
    Sci Adv  2022;8:eabo5555
  2. Pannexin-1 Activation by Phosphorylation Is Crucial for Platelet Aggregation and Thrombus Formation.
    Authors: Margitta Et al.
    Int J Mol Sci  2022;23
  3. PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism.
    Authors: Claudio Et al.
    Mol Oncol  2022;16:188-205
  4. Exosomes from EGFR-Mutated Adenocarcinoma Induce a Hybrid EMT and MMP9-Dependant Tumor Invasion.
    Authors: Aurélie Et al.
    Cancers (Basel)  2022;14
  5. Regulation of Stress-Activated Kinases in Response to Tacaribe Virus Infection and Its Implications for Viral Replication.
    Authors: Lucie Et al.
    Viruses  2022;14
  6. EGFR Activates a TAZ-Driven Oncogenic Program in Glioblastoma.
    Authors: Charles G Et al.
    Cancer Res  2021;81:3580-3592
  7. Gαq activation modulates autophagy by promoting mTORC1 signaling.
    Authors: Anna M Et al.
    Nat Commun  2021;12:4540
  8. Characterization of a novel compound that promotes myogenesis via Akt and transcriptional co-activator with PDZ-binding motif (TAZ) in mouse C2C12 cells.
    Authors: Kodaka Et al.
    PLoS One  2020;15:e0231265
  9. Wnt-induced activation of glucose metabolism mediates the in vivo neuroprotective roles of Wnt signaling in Alzheimer disease.
    Authors: Viviana I Et al.
    J Neurochem  2019;149:54-72
  10. Tyro3 is a podocyte protective factor in glomerular disease.
    Authors: Zhong Et al.
    JCI Insight  2018;3

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