Acetaminophen
Chemical Name: N-(4-Hydroxyphenyl)acetamide
Purity: ≥99%
Biological Activity
Acetaminophen is a cyclooxygenase inhibitor; may be selective for COX-3 (IC50 values are 460, > 1000 and > 1000 μM for canine COX-3, and murine COX-1 and COX-2 respectively). Widely used analgesic and antipyretic agent.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: cloning, structure, and expression.
Chandrasekharan et al.
Proc.Natl.Acad.Sci.U.S.A., 2002;99:13926 -
Effect of acetaminophen on atherosclerosis.
Chong et al.
Ann.Pharmacother., 2001;35:1476 -
Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDS) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays.
Riendeau et al.
Can.J.Physiol.Pharmacol., 1997;75:1088
Product Datasheets
Citations for Acetaminophen
The citations listed below are publications that use Tocris products. Selected citations for Acetaminophen include:
3 Citations: Showing 1 - 3
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Evaluation of drug-induced tissue injury by measuring alanine aminotransferase (ALT) activity in silkworm hemolymph.
Authors: Inagaki Et al.
J Neurosci 2012;13:13
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Adenosine inhibits activity of hypocretin/orexin neurons by the A1 receptor in the lateral hypothalamus: a possible sleep-promoting effect.
Authors: Liu and Gao
J Neurophysiol 2007;97:837
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Adenosine regulation of alveolar fluid clearance.
Authors: Factor Et al.
Proc Natl Acad Sci U S A 2007;104:4083
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