Ac-Cys-NHMe
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Description: Building block for the lysine acylation using conjugating enzymes (LACE) technique
Chemical Name: (2R)-2-(Acetylamino)-3-mercapto-N-methylpropanamide
Biological Activity
Ac-Cys-NHMe is a non-canonical amino acid that is an essential building block for lysine acylation using conjugating enzymes (LACE) technique. LACE is a chemoenzymatic approach that uses an E2 small ubiquitin-like modifier (SUMO)-conjugating enzyme, Ubc9, to conjugate peptide thioesters containing a C-terminal ubiquitin-derived sequence (LRLRGG) to a lysine residue located in a recognition sequence (IKQE) on a protein via an isopeptide bond. Ac-Cys-NHMe can be reacted with a peptide hydrazide to form a reactive peptide thioester, which is the substrate for Ubc9. LACE enables the site-specific modification of proteins at lysine residues to allow attachment of biochemical probes such as fluorophores to proteins or to engineer proteins for site-specific delivery.Technical Data
M.Wt:
176.23
Formula:
C6H12N2O2S
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in water
Storage:
Store at -20°C
CAS No:
10061-65-1
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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