A 971432

Catalog #: 5766
1 Citation Datasheet

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A 971432 | CAS No. 1240308-45-5 | Sphingosine-1-phosphate Receptor Agonists

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Description: Potent and selective S1P5 agonist

Chemical Name: 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid

Purity: ≥99%

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Product Details

Citations (1)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

A 971432 is a potent and selective S1P₅ agonist (EC₅₀ values are 4.1 and 5.7 nM in cAMP and GTPγS assays, respectively). Exhibits 60-fold selectivity over S1P₁, and >1,600-fold selectivity over S1P_2-4, and a panel of 129 kinases and 79 receptors. Improves blood-brain barrier integrity in vitro and reverses age-related cognitive decline in vivo. Orally available.

Technical Data

M.Wt:

366.24

Formula:

C₁₈H₁₇Cl₂NO₃

Solubility:

Soluble to 100 mM in 1eq. NaOH and to 100 mM in 1eq. HCl

Purity:

≥99%

Storage:

Store at RT

CAS No:

1240308-45-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of A-971432, an orally bioavailable selective sphingosine-1-phosphate receptor 5 (S1P₅) agonist for the potential treatment of neurodegenerative disorders.
Hobson et al.
J.Med.Chem., 2015;58:9154

Product Datasheets

COA view current batch

SDS

Citation for A 971432

The citations listed below are publications that use Tocris products. Selected citations for A 971432 include:

1 Citation: Showing 1 - 1

Sphingosine 1-phosphate (S1P) reduces hepatocyte growth factor-induced migration of hepatocellular carcinoma cells via S1P receptor 2.
Authors: Matsushima-Nishiwaki Et al.
PLoS One 2018;13:e0209050

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