A 286982

Catalog #: 4228
1 Citation Datasheet

Catalog #	Availability	Size / Price	Qty
4228/10
4228/50

A 286982 | CAS No. 280749-17-9 | Integrin Receptor Inhibitors

1 Image

Description: Potent inhibitor of the LFA-1/ICAM-1 interaction

Chemical Name: (2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one

Purity: ≥99%

View All Products for Integrin Receptor Inhibitors

Product Details

Citations (1)

Supplemental Products

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

A 286982 is a potent inhibitor of the LFA-1/ICAM-1 interaction (IC₅₀ values are 44 and 35 nM in LFA-1/ICAM-1 binding and LFA-1-mediated cell adhesion assays respectively).

Technical Data

M.Wt:

453.55

Formula:

C₂₄H₂₇N₃O₄S

Solubility:

Soluble to 100 mM in DMSO and to 50 mM in ethanol

Purity:

≥99%

Storage:

Store at RT

CAS No:

280749-17-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. Identification of an additional binding pocket based on an anilino diaryl sulfide lead.
Liu et al.
J.Med.Chem., 2000;43:4025

Product Datasheets

COA view current batch

SDS

Citation for A 286982

The citations listed below are publications that use Tocris products. Selected citations for A 286982 include:

1 Citation: Showing 1 - 1

Approaches for investigating the extracellular signaling function of ISG15.
Authors: Jon M Et al.
Methods Enzymol 2019;618:211-227

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for A 286982

There are currently no reviews for this product. Be the first to review A 286982 and earn rewards!

Have you used A 286982?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.