6-Hydroxy-DL-DOPA
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Description: Allosteric inhibitor of RAD52; also APE1 inhibitor
Chemical Name: 2,5-Dihydroxy-DL-tyrosine
Biological Activity
6-Hydroxy-DL-DOPA is an allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1.Technical Data
M.Wt:
213.19
Formula:
C9H11NO5
Solubility:
Soluble to 100 mM in 1M HCl
Storage:
Store at -20°C
CAS No:
21373-30-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small molecule inhibitors of DNA repair nuclease activities of APE1.
Wilson DM 3rd et al.
Cell Mol.Life Sci., 2010;67:3621 -
Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1.
Simeonov et al.
PLoS One, 2009;4:e5740 -
Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers.
Chandramouly et al.
Chem.Biol., 2015;22:1491
Product Datasheets
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