5-Carboxamidotryptamine maleate

Catalog #: 0458
14 Citations Datasheet

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0458/10
0458/50

5-Carboxamidotryptamine maleate | CAS No. 74885-72-6 | Non-selective 5-HT1 Receptor Agonists

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Description: 5-HT1 agonist; also has high affinity for 5-ht5a and 5-HT7

Alternative Names: AH-21467,5-CT

Purity: ≥99%

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Product Details

Citations (14)

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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

5-Carboxamidotryptamine maleate is a 5-HT₁ agonist with high affinity at 5-HT_1A, 5-HT_1B, 5-HT_1D, 5-ht₅ and 5-HT₇ receptors.

Technical Data

M.Wt:

319.32

Formula:

C₁₁H₁₃N₃O.C₄H₄O₄

Solubility:

Soluble to 100 mM in water

Purity:

≥99%

Storage:

Store at +4°C

CAS No:

74885-72-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8.
A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors

PLoS Pathog, 2016;12(5):e1005651.
Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
Kim, Janice J, Bridle, Byram W, Ghia, Jean-Eri, Wang, Huaqing, Syed, Shahzad, Manocha, Marcus M, Rengasamy, Palanive, Shajib, Mohammad, Wan, Yonghong, Hedlund, Peter B, Khan, Waliul I
J Immunol, 2013;190(9):4795-804.
[³H]-5-carboxamidotryptamine labels 5HT_1D binding sites in bovine substantia nigra.
Nowak et al.
Br.J.Pharmacol., 1993;109:1206
Antagonist activity of meta-chlorophenylpiperazine and partial agonist activity of 8-OH-DPAT at the 5-HT₇ receptor.
Wood et al.
Eur.J.Pharmacol., 2000;396:1
5-Hydroxytryptamine receptors.
Zifa and Fillion
Pharmacol.Rev., 1992;44:401
An investigation of the 5-HT_1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatr. in the central nervous system of seven species.
Beer et al.
Eur.J.Pharmacol., 1992;213:193

Product Datasheets

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Citations for 5-Carboxamidotryptamine maleate

The citations listed below are publications that use Tocris products. Selected citations for 5-Carboxamidotryptamine maleate include:

14 Citations: Showing 1 - 10

Synaptic Remodeling Depends on Signaling between Serotonin Receptors and the Extracellular Matrix
Authors: Bijata Et al.
Cell Rep 2017;19:1767
Chronic social isolation reduces 5-HT neuronal activity via upregulated SK3 calcium-activated potassium channels
Authors: Sargin Et al.
Elife 2016;5:e21416
A Miniaturized Screen of a Schistosoma mansoni Serotonergic G Protein-Coupled Receptor Identifies Novel Classes of Parasite-Selective Inhibitors.
Authors: Chan Et al.
PLoS Pathog 2016;12:e1005651
5-hydroxytryptamine has an endothelium-derived hyperpolarizing factor-like effect on coronary flow in isolated rat hearts.
Authors: Chien and Su
PLoS One 2015;22:42
Pharmacological Characterization of 5-HT1A Autoreceptor-Coupled GIRK Channels in Rat Dorsal Raphe 5-HT Neurons.
Authors: Montalbano Et al.
Br J Pharmacol 2015;10:e0140369
Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor.
Authors: Gantz Et al.
Am J Physiol Renal Physiol 2013;78:807
Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation.
Authors: Kim Et al.
Neuron 2013;190:4795
Polysynaptic excitatory postsynaptic potentials that trigger spasms after spinal cord injury in rats are inhibited by 5-HT1B and 5-HT1F receptors.
Authors: Murray Et al.
J Neurophysiol 2011;106:925
5-hydroxytryptamine modulates migration, cytokine and chemokine release and T-cell priming capacity of dendritic cells in vitro and in vivo.
Authors: Müller Et al.
PLoS One 2009;4:e6453
Serotonin targets inhibitory synapses to induce modulation of network functions.
Authors: Manzke Et al.
Philos Trans R Soc Lond B Biol Sci 2009;364:2589

Frequency-dependent modulation of retinogeniculate transmission by serotonin.
Authors: Seeburg Et al.
J Neurosci 2004;24:10950

Increased contractile response to 5-hydroxytryptamine1-receptor stimulation in pulmonary arteries from chronic hypoxic rats: role of pharmacological synergy.
Authors: Maclean and Morecroft
Br J Pharmacol 2001;134:614

5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
Authors: Morecroft Et al.
J Immunol 1999;128:730

Involvement of 5-HT1B receptors in collar-induced hypersensitivity to 5-hydroxytryptamine of the rabbit carotid artery.
Authors: Geerts Et al.
Br J Pharmacol 1999;127:1327

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