5,7-Dichlorokynurenic acid sodium salt
Chemical Name: 5,7-Dichloro-4-hydroxyquinoline-2-carboxylic acid sodium salt
Purity: ≥98%
Biological Activity
5,7-Dichlorokynurenic acid sodium salt is a sodium salt of 5,7-Dichlorokynurenic acid (Cat. No. 0286), a potent antagonist at the glycine site of the NMDA receptor (Ki = 79 nM vs. [3H]-glycine).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Activity of 5,7-dichlorokynurenic acid. A potent antagonist at the NMDA receptor-associated glycine binding site.
Baron et al.
Mol.Pharmacol., 1990;38:554 -
Substituted kynurenic acid derivatives. Potent and selective antagonists at the glycine site on the NMDA receptor.
Moore et al.
Eur.Fed.Med.Chem. (under auspices of IUPAC) XIth I, 1990;
Product Datasheets
Citations for 5,7-Dichlorokynurenic acid sodium salt
The citations listed below are publications that use Tocris products. Selected citations for 5,7-Dichlorokynurenic acid sodium salt include:
2 Citations: Showing 1 - 2
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GluN3A excitatory glycine receptors control adult cortical and amygdalar circuits.
Authors: Rafael Et al.
Neuron 2022;110:2438-2454.e8
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Differences in the Conformational Energy Landscape of CDK1 and CDK2 Suggest a Mechanism for Achieving Selective CDK Inhibition.
Authors: Lan-Zhen Et al.
Cell Chem Biol 2019;26:121-130.e5
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