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3-Methyladenine

Catalog #: 3977
10 Citations Datasheet
Catalog # Availability Size / Price Qty
3977/50
3-Methyladenine | CAS No. 5142-23-4 | PI 3-Kinase Inhibitors
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Description: Class III PI 3-kinase inhibitor; also inhibits autophagy
Alternative Names: 3-MA

Chemical Name: 3-Methyl-3H-purin-6-amine

Purity: ≥99%

Product Details
Citations (10)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

3-Methyladenine is an inhibitor of class III phosphatidylinositol 3-kinase (PI 3-kinase); also inhibits the autophagic sequestration of cell proteins in rat hepatocytes. Blocks apoptosis in cerebellar granule cells (CGCs) following serum and potassium deprivation.

Technical Data

M.Wt:
149.15
Formula:
C6H7N5
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
5142-23-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes.
    Blommaart et al.
    Eur.J.Biochem., 1997;243:240
  2. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells.
    Canu et al.
    J.Neurochem., 2005;92:1228
  3. Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients
    RK Ramakrishn, K Bajbouj, MY Hachim, AK Mogas, B Mahboub, R Olivenstei, R Hamoudi, R Halwani, Q Hamid
    PLoS ONE, 2020;15(11):e0242695.

Product Datasheets

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Citations for 3-Methyladenine

The citations listed below are publications that use Tocris products. Selected citations for 3-Methyladenine include:

10 Citations: Showing 1 - 10

  1. β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME.
    Authors: Scott I Et al.
    Cell Rep  2021;37:109883
  2. Ginsenoside Rh1 Induces MCF-7 Cell Apoptosis and Autophagic Cell Death through ROS-Mediated Akt Signaling.
    Authors: Kyung-Sun Et al.
    Cancers (Basel)  2021;13
  3. Gliotoxin Enhances Autophagic Cell Death via the DAPK1-TAp63 Signaling Pathway in PTX-Resistant Ovarian Cancer Cells.
    Authors: Park Et al.
    Mar Drugs  2019;17
  4. Junín virus induces autophagy in human A549 cells.
    Authors: Vidakovics Et al.
    PLoS One  2019;14:e0218730
  5. Melatonin: The smart molecule that differentially modulates autophagy in tumor and normal placental cells.
    Authors: Sagrillo-Fagundes Et al.
    PLoS One  2019;14:e0202458
  6. A role for autophagy in long-term spatial memory formation in male rodents.
    Authors: Hylin Et al.
    J Neurosci Res  2018;96:416
  7. Autophagy induction by leptin contributes to suppression of apoptosis in cancer cells and xenograft model: involvement of p53/FoxO3A axis.
    Authors: Nepal Et al.
    Evid Based Complement Alternat Med  2015;6:7166
  8. Miz1 is required to maintain autophagic flux.
    Authors: Wolf Et al.
    Clin Transl Med  2013;4:2535
  9. Epigallocatechin gallate (EGCG) stimulates autophagy in vascular endothelial cells: a potential role for reducing lipid accumulation.
    Authors: Kim Et al.
    J Biol Chem  2013;288:22693
  10. Active Constituents from Liriope platyphylla Root against Cancer Growth In Vitro.
    Authors: Wang Et al.
    Nat Commun  2013;2013:857929

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