3-AP
Chemical Name: 2-[(3-Amino-2-pyridinyl)methylene]hydrazinecarbothioamide
Purity: ≥98%
Biological Activity
3-AP is a ribonucleotide reductase inhibitor. Also an iron chelator. Inhibits leukemia cell growth and acts in synergy with cisplatin (Cat. No.2251). Active in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Synthesis and antitumor activity of amino derivatives of pyridine-2-carboxaldehyde thiosemicarbazone.
Liu et al.
J.Med.Chem., 1992;35:3672 -
Nucleotide metabolism, oncogene-induced senescence and cancer.
Arid et al.
Cancer Letters, 2015;356:204 -
Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone; 3-AP): an inhibitor of ribonucleotide reductase with antineoplastic activity.
Finch et al.
Adv.Enzyme Regul., 1999;39:3
Product Datasheets
Citation for 3-AP
The citations listed below are publications that use Tocris products. Selected citations for 3-AP include:
1 Citation: Showing 1 - 1
-
Iron-targeting antitumor activity of gal. compounds and novel insights into triapine(®)-metal complexes.
Authors: Chitambar Et al.
Antioxid.Redox Signal. 2013;18:956
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for 3-AP
There are currently no reviews for this product. Be the first to review 3-AP and earn rewards!
Have you used 3-AP?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
