2A3
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Description: Reagent for RNA SHAPE-MaP experiments in vivo; cell permeable
Chemical Name: (2-Aminopyridin-3-yl)(1H-imidazol-1-yl)methanone
Biological Activity
2A3 is an electrophilic chemical probe that acylates the 2'-OH in the RNA backbone. 2A3 can be used for RNA SHAPE-MaP experiments in cell lines or live bacteria. It labels single-stranded or flexible regions more than folded regions (SHAPE methodology) and enables analysis of RNA secondary structures at single nucleotide resolution. For intracellular experiments, 2A3 has higher signal-to-noise ratio and prediction accuracy than NAI (Cat. No. 7004). 2A3 is cell permeable, and can probe both gram-positive and gram-negative bacteria.Technical Data
M.Wt:
188.19
Formula:
C9H8N4O
Solubility:
Soluble to 100 mM in DMSO
Storage:
Store at -20°C
CAS No:
2765091-45-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold with kind permission of Dr Danny Incarnato
Product Datasheets
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