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27-Hydroxycholesterol

Catalog #: 3907
2 Citations Datasheet
Catalog # Availability Size / Price Qty
3907/10
27-Hydroxycholesterol | CAS No. 20380-11-4 | LXR-like Receptor Agonists
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Description: LXR agonist; also ER partial agonist
Alternative Names: 27 OHC,27 HC

Chemical Name: (3β,25R)-Cholest-5-ene-3,26-diol

Purity: ≥95%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

27-Hydroxycholesterol is a liver X receptor (LXR) agonist. Also estrogen receptor partial agonist. Suppresses β-estradiol-mediated breast cancer cell proliferation in vitro. Also increases α-synuclein levels and induces apoptosis in human neuroblastoma cells in vitro. Endogenous cholesterol metabolite.

Technical Data

M.Wt:
402.65
Formula:
C27H46O2
Solubility:
Soluble to 20 mM in ethanol
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
20380-11-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for 27-Hydroxycholesterol

The citations listed below are publications that use Tocris products. Selected citations for 27-Hydroxycholesterol include:

2 Citations: Showing 1 - 2

  1. The impact of 27-hydroxycholesterol on endometrial cancer proliferation.
    Authors: Gibson Et al.
    Endocr Relat Cancer  2018;25:381
  2. 27-Hydroxycholesterol increases α-synuclein protein levels through proteasomal inhibition in human dopaminergic neurons.
    Authors: Schommer Et al.
    BMC Neurosci  2018;19:17

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