Home / Histamine H1 Receptor Agonists / 2-Pyridylethylamine dihydrochloride

2-Pyridylethylamine dihydrochloride

Catalog #: 2478
2 Citations Datasheet
Catalog # Availability Size / Price Qty
2478/50
2-Pyridylethylamine dihydrochloride | CAS No. 3343-39-3 | Histamine H1 Receptor Agonists
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Description: H1 agonist

Chemical Name: 2-Pyridineethanamine dihydrochloride

Purity: ≥99%

Product Details
Citations (2)
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Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

2-Pyridylethylamine dihydrochloride is a histamine H1 receptor agonist that produces vasoconstriction in vivo.

Technical Data

M.Wt:
195.09
Formula:
C7H10N2.2HCl
Solubility:
Soluble to 100 mM in water and to 50 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
3343-39-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Histamine induces proliferation in keratinocytes from patients with atopic dermatitis through the histamine 4 receptor.
    Glatzer F, Gschwandtner M, Ehling S, Rossbach K, Janik K, Klos A, Baumer W, Kietzmann M, Werfel T, Gutzmer R
    J Allergy Clin Immunol, 2013;132(6):1358-67.
  2. Effect of histamine and histamine analogues on human isolated myometrial strips.
    Martinez-Mir et al.
    Br.J.Pharmacol., 1992;107:528
  3. Endothelium-dependent vasodilation mechanisms by histamine in simian but not in canine femoral arterial branches.
    Arai and Chiba
    J.Auton.Pharmacol., 1999;19:267

Product Datasheets

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Citations for 2-Pyridylethylamine dihydrochloride

The citations listed below are publications that use Tocris products. Selected citations for 2-Pyridylethylamine dihydrochloride include:

2 Citations: Showing 1 - 2

  1. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.
    Authors: Jain Et al.
    Am J Physiol Endocrinol Metab  2018;315:E357
  2. Histamine Induces Vascular Hyperpermeability by Increasing Blood Flow and Endothelial Barrier Disruption In Vivo.
    Authors: Ashina Et al.
    Mol Med Rep  2015;10:e0132367

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