Home / Other Reductase Inhibitors / 1S,3R-RSL3

1S,3R-RSL3

Catalog #: 6118
4 Citations Datasheet
Catalog # Availability Size / Price Qty
6118/50
6118/10
1S,3R-RSL3 | CAS No. 1219810-16-8 | Other Reductase Inhibitors
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Description: Inhibits glutathione peroxidase (GPX4); induces ferroptosis

Chemical Name: (1S,3R)-Methyl 2-(2-chloroacetyl)-2,3,4,9-tetrahydro-1-[4-(methoxycarbonyl)phenyl]-1H-pyrido[3,4-b]indole-3-carboxylate

Purity: ≥98%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

1S,3R-RSL3 is a glutathione peroxidase 4 (GPX4) inhibitor. Induces ferroptosis. Increases lipid peroxidase levels in vitro. Inhibits tumor formation and progression in vivo.

Negative control 1R,3R-RSL3 (Cat. No. 6687) also available.

Technical Data

M.Wt:
440.88
Formula:
C23H21ClN2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1219810-16-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Columbia University.

Background References

  1. Unsolved mysteries: How does lipid peroxidation cause ferroptosis?
    Feng & Stockwell et al.
    PLoS. Biol., 2018;16:e2006203
  2. Regulation of ferroptotic cancer cell death by GPX4.
    Yang et al.
    Cell, 2014;156:317
  3. Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis.
    Yang et al.
    Proc.Natl.Acad.Sci.U.S.A., 2016;113:E4966

Product Datasheets

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Citations for 1S,3R-RSL3

The citations listed below are publications that use Tocris products. Selected citations for 1S,3R-RSL3 include:

4 Citations: Showing 1 - 4

  1. Effect of erythrophagocytosis-induced ferroptosis during angiogenesis in atherosclerotic plaques.
    Authors: Guido R Y Et al.
    Angiogenesis  2023;
  2. Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.
    Authors: Eva Et al.
    Cancer Cell  2020;37:55-70.e15
  3. Combined Knockout of RIPK3 and MLKL Reveals Unexpected Outcome in Tissue Injury and Inflammation.
    Authors: Stefan Et al.
    Front Cell Dev Biol  2019;7:19
  4. Metadherin enhances vulnerability of cancer cells to ferroptosis.
    Authors: Bi Et al.
    Cell Death Dis  2019;10:682

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