1M7
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Description: Reagent for RNA SHAPE-MaP chemistry
Alternative Names: 1-Methyl-7-nitroisatoic anhydride
Chemical Name: 1-Methyl-7-nitro-2H-3,1-benzoxazine-2,4(1H)-dione
Purity: ≥95%
Biological Activity
1M7 is a reagent for RNA SHAPE-MaP experiments. Enables analysis of RNA secondary structures at single nucleotide resolution in <70 seconds.Technical Data
M.Wt:
222.15
Formula:
C9H6N2O5
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥95%
Storage:
Store at -20°C
CAS No:
73043-80-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
A fast-acting reagent for accurate analysis of RNA secondary and tertiary structure by SHAPE chemistry.
Mortimer et al.
J.Am.Chem.Soc., 2007;129:4144 -
Safer one-pot synthesis of the 'SHAPE' reagent 1-methyl-7-nitroisatoic anhydride (1m7).
Turner et al.
RNA, 2013;19:1857 -
RNA motif discovery by SHAPE and mutational profiling (SHAPE-MaP).
Siegfried et al.
Nat.Methods, 2014;11:959 -
Detection of RNA-Protein interactions in living cells with SHAPE.
Smola et al.
Biochemistry, 2015;54:6867
Product Datasheets
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