17-AAG

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. The hsp70 inhibitor VER155008 induces paraptosis requiring de novo protein synthesis in anaplastic thyroid carcinoma cells.
   Kim S, Kang J, Kim C, Ihm S, Choi M, Yoo H, Lee S
   Biochem Biophys Res Commun, 2014;454(1):36-41.
2. Heat shock protein 90 (Hsp90) promotes opioid-induced anti-nociception by an ERK Mitogen Activated Protein Kinase (MAPK) mechanism in mouse brain
   W Lei, N Mullen, S McCarthy, C Brann, P Richard, J Cormier, K Edwards, EJ Bilsky, JM Streicher
   J. Biol. Chem., 2017;0(0):.
3. Protection of murine neural progenitor cells by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin in the low nanomolar concentration range.
   Wang et al.
   J.Neurochem., 2011;117:703
4. Inhibition of signal transduction by the Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin results in cytostasis and apoptosis.
   Hostein et al.
   Cancer Res., 2001;61:4003
5. Inhibition of the oncogene product p185^erbB-2 in vitro and in vivo by geldanamycin and dihydrogeldanamycin derivatives.
   Schnur et al.
   J.Med.Chem., 1995;38:3806
6. Disruption of the EF-2 kinase/Hsp90 protein complex: a possible mechanism to inhibit glioblastoma by geldanamycin.
   Yang et al.
   Cancer Res., 2001;61:4010

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