1,6-Hexanediol

Biological Activity

1,6-Hexanediol is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells. Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo. Dissolves LLPS condensates, such as P bodies, but not solid-like condensates, such as protein aggregates and cytoskeletal assemblies.Typically used as a 3-10% solution (w/v). Disrupts cellular structures in yeast and alters cellular morphology in HeLa cells.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division.
   Shan et al.
   Nat.Commun., 2018;9:737
2. Distinct stages in stress granule assembly and disassembly.
   Wheeler et al.
   Elife, 2016;5:e18413
3. Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments.
   Kroschwald et al.
   Matters, 2017;

Product Datasheets