¹⁰Panx

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. The P2X7 Receptor Primes IL-1? and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain
   F Albalawi, W Lu, JM Beckel, JC Lim, SA McCaughey, CH Mitchell
   Front Cell Neurosci, 2017;11(0):227.
2. CR1-mediated ATP release by human red blood cells promotes CR1 clustering and modulates the immune transfer process.
   Melhorn M, Brodsky A, Estanislau J, Khoory J, Illigens B, Hamachi I, Kurishita Y, Fraser A, Nicholson-Weller A, Dolmatova E, Duffy H, Ghiran I
   J Biol Chem, 2013;288(43):31139-53.
3. Pannexin-1 in Human Lymphatic Endothelial Cells Regulates Lymphangiogenesis
   J Boucher, C Simonneau, G Denet, J Clarhaut, AC Balandre, M Mesnil, L Cronier, A Monvoisin
   Int J Mol Sci, 2018;19(6):.
4. Slc11a1 (Nramp1) impairs growth of Salmonella enterica serovar typhimurium in macrophages via stimulation of lipocalin-2 expression.
   Fritsche G, Nairz M, Libby S, Fang F, Weiss G
   J Leukoc Biol, 2012;92(2):353-9.
5. A central role for P2X7 receptors in human microglia
   L Janks, CVR Sharma, TM Egan
   J Neuroinflammation, 2018;15(1):325.
6. Pannexin-1 mediates large pore formation and interleukin-1β; release by the ATP-gated P2X₇ receptor.
   Pelegrin and Surprenant
   EMBO J., 2006;25:5071
7. Modulation of membrane channel currents by gap junction protein mimetic peptides: size matters.
   Wang et al.
   Am.J.Physiol.Cell Physiol., 2007;293:C1112
8. Activation of pannexin-1 hemichannels augments aberrant bursting in the hippocampus.
   Thompson et al.
   Science, 2008;322:1555

Product Datasheets