1-Oleoyl lysophosphatidic acid sodium salt
Chemical Name: 1-O-9Z-Octadecenoyl-sn-glyceryl-3-phosphoric acid sodium salt
Biological Activity
1-Oleoyl lysophosphatidic acid sodium salt is an endogenous agonist of the lysophospholipid receptors LPA1 and LPA2. 1-Oleoyl lysophosphatidic acid sodium salt inhibits differentiation of neural stem cells (NSCs) into neurons.Note: This product is typically prepared in PBS, pH 7.2, at a concentration of up to approximately 4 mg/mL.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Lysophosphatidic acid inhibits neuronal differentiation of neural stem/progenitor cells derived from human embryonic stem cells.
Dottori M, Leung J, Turnley AM et al.
Stem Cells. -
Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts.
van Corven et al.
Biochem.J., 1992;281:163 -
Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival.
Lapierre DM, Tanabe N, Pereverzev A
J. Biol. Chem., 2010-06-15;285(33):25792-801.
Product Datasheets
Citations for 1-Oleoyl lysophosphatidic acid sodium salt
The citations listed below are publications that use Tocris products. Selected citations for 1-Oleoyl lysophosphatidic acid sodium salt include:
10 Citations: Showing 1 - 10
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Generating human blastoids modeling blastocyst-stage embryos and implantation.
Authors: Maria Et al.
Nat Protoc 2023;18:1584-1620
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Human blastoids model blastocyst development and implantation.
Authors: Maria Et al.
Nature 2022;601:600-605
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Modeling human extraembryonic mesoderm cells using naive pluripotent stem cells.
Authors: Janet Et al.
Cell Stem Cell 2022;29:1346-1365.e10
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Integrated multi-omics reveal polycomb repressive complex 2 restricts human trophoblast induction.
Authors: Natarajan V Et al.
Nat Cell Biol 2022;24:858-871
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A pendulum of induction between the epiblast and extra-embryonic endoderm supports post-implantation progression.
Authors: Jop Et al.
Development 2022;149
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Human embryos in a dish - modeling early embryonic development with pluripotent stem cells.
Authors: Guang Et al.
Cell Regen 2022;11:4
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Activation of Macrophages by Lysophosphatidic Acid through the Lysophosphatidic Acid Receptor 1 as a Novel Mechanism in Multiple Sclerosis Pathogenesis.
Authors: Fernando Rodríguez Et al.
Mol Neurobiol 2021;58:470-482
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α-Arrestin ARRDC3 tumor suppressor function is linked to GPCR-induced TAZ activation and breast cancer metastasis.
Authors: JoAnn Et al.
J Cell Sci 2021;134
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A Differential Hypofunctionality of Gαi Proteins Occurs in Adolescent Idiopathic Scoliosis and Correlates with the Risk of Disease Progression.
Authors: Akoume Et al.
Sci Rep 2019;9:10074
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Cortical contractility triggers a stochastic switch to fast amoeboid cell motility.
Authors: Ruprecht Et al.
J Clin Invest 2015;160:673
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